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10.1098/rstb.2016.0286 Philos

We have no idea how long that immunosuppression lasts

Without adequate antioxidant protection, these radicals can damage proteins, DNA, and cellular membranes

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The results of qRT-PCR and Western blot suggested that IGF-1R mRNA and protein levels were reduced in the Y-56 mimics group than in the mimics-NC group, (Figures 4EG

Under the combined influence of inflammatory mediators and oxidative stress, chondrocytes undergo chondroaging, characterized by mitochondrial dysfunction, disordered cellular metabolism, reduced SIRT1 activity, and impaired autophagy