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The lipid bilayer protects this drug from degradation and thereby enables its accumulation in tumor tissues through the EPR effect

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The three new L1 GUS enzymes also retain the same tetramer organization compared to previously determined L1 structures, in which GUS monomers are in a C-term-mediated tetrameric state rather than a square tetrameric state, as exhibited by mL1 Bf GUS (PDB: 3CMG) and discussed below (Figs 2b and S2) 17,21

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