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POPs are mainly excreted through conjugation with GSH and this mechanism is extremely important for the health status, since exposure to POPs has been associated to diabetes, cardiovascular diseases and many other chronic diseases (1, 13)

10.1371/journal.pone.0097774 PLoS One 58 RouillonA.BarbeyR.PattonE

PMID: 6600947

[28] found that NNMT knockdown significantly reduced the body weight, fat mass, and insulin level of female mice fed a Western diet (fat 47% kcal, carbohydrate 34% kcal), as did NNMT knockout

The downregulation of MT1G, caused by hypermethylation of its promoter, is associated with the maintenance of pancreatic cancer stemness

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