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Kobayashi M., Kato H., Hada H., ItohNakadai A., Fujiwara T., Muto A., Inoguchi Y., Ichiyanagi K., Hojo W., Tomosugi N., Sasaki H., Harigae H., Igarashi K., Haematologica 2017, 102, 454

Hence, antioxidant therapy in context of counteracting the harmful effects of ROS and therefore preventing or treating oxidative stress-related diseases is a noteworthy therapeutic option

FEBS Letters 238(2):343-346. [doi.org]

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Similarly, rats harboring the same DMT1 G185R mutation show reduced susceptibility to 6-hydroxydopamine (6-OHDA)-induced neurotoxicity, with 42.6% dopaminergic neuron loss versus 61.6% in wild-type and 65.9% in heterozygous animals ( Lysosomes serve as dynamic iron reservoirs and key regulators of cellular iron homeostasis