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(2014) 5:e10833

The Nrf2 protein encoded by the corresponding NFE2L2 gene is one of the key transcription factors sensing ROS accumulation and other stress stimuli

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This 3-6 fold increase in oxalate absorption is significant, especially if paired with a genetic susceptibility or with a high oxalate diet.[ref] Enteric hyperoxaluria is a metabolic disorder that is primarily due to increased absorption of dietary oxalates