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DUSP22 knockout results in a reduction of vascular hemorrhage in the skin tissue of LPS plus TNF-stimulated mice [245]

In vitro studies, although useful for clarifying molecular pathways as NF-B suppression, antioxidant enzyme overexpression, sometimes employ elevated, non-physiological concentrations of extracts and may fail to correctly simulate the complex context of the human eye

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Leyane TS, Jere SW, Houreld NN (2022) Oxidative stress in ageing and chronic degenerative pathologies: molecular mechanisms involved in counteracting oxidative stress and chronic inflammation