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According to structural studies published in Nature Communications, the peptide binds to the disordered p53 transactivation domain and forms a transiently folded complex

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Cell Calcium 18 , 177186 (1995)

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The ability of these HLA class II alleles to recognize a greater number of antigens and to stimulate a greater number of T and B cells could increase the probability of activation of autoreactive T cells due to their promiscuous nature (112)

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