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discussion 890-1, 2010

GLOBOCAN-2022 recorded 324,398 new cases and 206,839 deaths worldwide, and demographic modelling predicts that annual incidence will exceed half a million by 2050, with the greatest absolute growth in Asia and the steepest percentage rise in sub-Saharan Africa [38]

Hypercholesterolemia also drives HSPC proliferation and myeloid skewing, producing proinflammatory, pro-atherogenic myeloid cells (105)

We examine dysfunction across various conditions and analyze emerging therapeutic approaches targeting thermogenic activation and cellular senescence pathways, providing an integrated framework for understanding metabolic disease pathogenesis and identifying novel intervention strategies