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These two effects then jointly lead to accumulation of cellular NO, ROS and lipid-ROS, and ultimately ferroptotic cell death

The strongest gene expression changes include upregulation of S-assimilation pathway genes SULTR1;1 Os03g0195800, SULTR4;1 Os09g0240500, ATPS 0s03g0743900, APRL1 Os07g0509800, SAT Os05g0533500, and OASTL Os12g0625000

Genetic variants that impact the carboxyl-terminal domain of FTL and modify its iron-binding capacity have been linked to the disease hereditary neuroferritinopathy, it is characterized by progressive neurologic symptoms and iron accumulation, particularly in the basal ganglia

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Pharmacokinetics, pharmacodynamics, safety, and tolerability of pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor in overweight or obese, but otherwise healthy human subjects