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Nopeptides support, but do not replace, foundational lifestyle changes

We attribute the challenges of identifying APR-246 responsive mutants to these factors

G, PP, and JC worked on the manuscript

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63 Proteomic analyses further suggest selective depletion of C-terminal degrons in eukaryotic proteins, supporting the existence of C-end rules that shape proteome composition

HFHSD DKO mice were resistant to weight gain and accumulation of white adipose tissue compared to WT mice, which was unaffected by BA feeding