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However, chronic peripheral stimuli, such as microbial metabolites, endotoxins, and systemic cytokines, gradually convert immune cells into primed, hyper-responsive states that do not resolve [134]

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Critically, these two pathways do not operate independently

Research on MOTS-c in ovariectomized mice (a model for postmenopausal metabolic dysfunction) showed reduced fat accumulation in white adipose tissue, increased brown fat activation, and improved insulin sensitivity after just 5 weeks of treatment

As a result, the study is underpowered, and the observed findingsincluding a 44.4% clinical pregnancy rate after PRPshould be interpreted with caution as preliminary, hypothesis-generating evidence

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