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The process by which cytochrome b5 reductase and cytochrome b5 reduce hemoglobin in the presence of NADH probably involves three steps

29,30 Norrin interacts with both the CRD domain of FZD4 and ectodomain ECD of LRP5/6 by simulating the finger-like loop of Wnt (the structure of Wnt interacts with the CRD domain of FZD), thereby activating the Wnt/-catenin signalling pathway

and thyroid function: A mendelian randomization study

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