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For patients with CNS relapse, induction treatment consists of weekly triple intrathecal therapy (ITT) with methotrexate, hydrocortisone, and cytarabine until complete clearance of blasts in the cerebrospinal fluid, followed by 610 more spaced out ITT cycles as consolidation.7 Conclusions - current outcomes and perspectives APL is a very common subtype of AML in Latin American countries, unique for its maturation arrest in promyelocytes and close association with the characteristic molecular alteration, t(15;17)(q24.1;q21.2), along with a pronounced tendency towards coagulopathy, bleeding, and early death