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Increases Blood Flow

IGF-1 promotes MSC chondrogenic differentiation and chondrocyte proliferation mainly through the activation of IGF-1R

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They significantly decrease markers of oxidative stress (ROS, NO) and inflammation ( TNF- , IL-1 ), while modulating pathways involved in lipid metabolism ( PPAR- ) and antioxidant defense ( HO-1 , Nrf2 ), with the latter extract specifically shown to suppress the TLR4/MyD88/NF-B signaling pathway (Xiong et al., 2019