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Tirzepatide is a dual GIP/GLP-1 receptor agonist that produces mean body weight reductions of 20.9% at 72 weeks by delaying gastric emptying, suppressing ghrelin rebound, and enhancing glucose-dependent insulin secretion

Therefore, further clinical trials are necessary to validate their therapeutic efficacy

Phys Chem Chem Phys 13:99299941

Oxidative stress and 4-hydroxy-2-nonenal (4-HNE): implications in the pathogenesis and treatment of aging-related diseases

and D.K.Y

AGEs and ferroptosis AGEs induced oxidative stress and ferroptosis Although hyperglycemia-induced AGEs can trigger oxidative stress, importantly, this pathological state does not directly lead to diabetic complications