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Our findings demonstrated that metformin alleviated OA progression against oxidative stress through the activation of Nrf2 signaling pathway, which suggest the potential therapeutic option of metformin for osteoarthritis

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However, mutation of MSH6 alone usually is associated with loss of MSH6 protein but retention of MSH2 by immunohistochemistry

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Consequently, the primary cytokines that were recognized at that time to be responsible for immune functions, such as interleukin (IL)-1, IL-6, and IL-2, as well as the soluble IL-2 receptor (sIL-2R), were investigated