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Pernicious anaemia is a common cause in the UK

Because it stems from a systemic vascular condition, it commonly affects both legs, creating a matched pattern of discomfort

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Functional supercomplexes of the oxidative phosphorylation comprising respirasome, ATP-synthase, and other multienzyme complexes of associated metabolic pathways are held together in the negative bends of the inner leaf of the inner mitochondrial membrane with the help of cardiolipin and phosphatidylethanolamine (Figure 3) [15]