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However, the bioavailability of these drugs is limited, leading to various adverse reactions [8,9,10,11]

Interestingly, transfection of neurons with a cDNA construct, in which the pre-pro-domain of BDNF is fused to the mature part of the neurotrophin-4 (NT-4) redirects this BDNF-NT-4 chimera efficiently into vesicles of the regulated secretory pathway, whereas wildtype NT-4 is predominantly located in vesicles of the constitutive secretory pathway (Brigadski et al

In recent years, viral vector-mediated genes have opened up more possibilities for treating neurological diseases

HDL-C transports excess free cholesterol as cholesteryl esters from peripheral tissues and macrophages to the liver through so-called reverse cholesterol transport (RCT) [53]

They act on convergent immunological targets while offering the potential for safer and complementary use alongside synthetic agents