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Treatment Recommendations with Fumaric Acid Esters As a summary of treatment recommendations, it is advised to start with a low dose of a FAE then increase to the optimal dose by monitoring efficacy and side-effects

Since YAP/TAZ are known mechanotransducers, they likely play a role with VEGFR-2 in angiogenic response to mechanical forces

Interacting with the insulin receptor, which helps promote cell growth and regulate blood glucose levels throughout the body (thereby improving glucose uptake and metabolic function) Increasing the number and size of myofibrils while improving sarcomere organization, leading to a boost in skeletal muscle fiber growth