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From target discovery to clinical drug development with human genetics

Track moisturizer consumption as a proxy for barrier function

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Results: The top metabolites discriminating MetALD from MASLD were Acetoacetate (OR:1.30, 95%1.21-1.41 p=1,48E-11), 3-Hydroxybutyrate (OR:1.29, 95%1.20-1.39 p=1,72E-11), Phospholipids in Large HDL (OR:1.20, 95%1.16-1.23 p=1,85E-32), Concentration of Large HDL Particles, Free Cholesterol in Large HDL, Cholesterol in Large HDL, Cholesteryl Esters in Large HDL, Total Lipids in Large HDL, Free, Cholesterol in Medium HDL, Cholesterol in Medium HDL

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Under oxidative stress, neurons can use glucose to maintain their antioxidant state through PPP (Herrero-Mendez et al., 2009)