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The published experience does not contain reports of fetal demise following acute single APAP ingestions if NAC therapy is begun promptly

Although the theoretical limitations have been addressed, clinical experiments are necessary to validate the findings based on cell and animal studies

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[PubMed: 19695740] (Editorial regarding Yarema [2009] discussing the shortcomings of data on the optimal regimen of N-acetylcysteine therapy for acetaminophen overdose)