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Likewise, ChREBP knockout protected against fructose-induced steatosis in mice, but substantially increased histological liver damage as a result of enhanced cholesterol synthesis and subsequent cytotoxicity [50]

Takakura Y, Masuda S, Tokuda H, Nishikawa M, Hashida M

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Phototransduction, phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (RPE) and the oxidization of polyunsaturated fatty acids (PUFAs) in the retina leads to the chronic production of ROS (64)