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The studies that achieved improvements in high-intensity (80% O 2 max ) exercise performance used acute doses of 3 to 4 g of l-C or GPL-C ingested between 60 and 90 min before exercise and chronic doses of 2 to 2.72 g/day of l-C for longer periods up to 9 to 24 weeks

Histidine catabolism is a major determinant of methotrexate sensitivity

From this perspective, nutritional interventions emerge as promising tools within the realm of preventive and/or adjunct therapeutic approaches, framing the concept of immunonutrition, a branch of precision nutrition aimed to fine tune pro- or anti-inflammatory immunophenotypes through personalized protocols tailored to individual requirements, health status and metabolic variability (337)

The group with low testosterone levels had a 33 percent greater risk of death during the next 18 years than the men with higher testosterone