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IR-A is predominantly found in the brain, particularly in the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, and cerebellum

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In individuals with type 2 diabetes with chronic hyperglycaemia or in those treated with sulfonylureas, pancreatic beta cells are chronically depolarised, which in turn leads to a switch from G as to G aq as the major pathway for stimulating insulin secretion [64]

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According to the model fit, GSH amounts are not significantly reduced by its degradation with DEM