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The Bottom Line Vitamin B12 is an essential water-soluble nutrient involved in energy metabolism, cognition, nervous system health, and more

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Emerging evidence suggests that it functions as a central coordinator, ensuring that mitochondrial biogenesis is coupled with the regulation of mitochondrial morphology and the removal of damaged organelles, thereby maintaining a healthy and functional mitochondrial network

The nuclei were detected in the blue channel by thresholding (applying the same offset values for every image), and intensity analysis of the nuclear fluorescence signal in the red channel was performed

Zhang L, Gu Y, Li H, Cao H, Liu B, Zhang H, Shao F (2018) Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response