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Campione et al 20 found that enzyme glutathione-s-transferase-pi (GST-pi), present in keratinocytes and melanocytes, protects cells against tumor progressionnotably, sun exposure-associated melanoma cells

it is activated by rising levels of ROS and/or its substrate, i.e., GSSG

The results demonstrated that excluding individual studies did not significantly alter the pooled effect estimates, indicating the robustness of this meta-analysis

Calabrese and Blain, The stress challenges that trigger hormesis include exposure to pollutants, toxins, natural products, caloric restriction, ischemic pre-conditioning, ionizing radiation, and many other stimuli (Schmitt et al., 2002

doi:10.1111/ijcp.14852

The preservative properties of the water also reduce the chance of contamination