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The needle should be angled 60 to 70 degrees to the plane of the foot and pointed distally to match the slope of the joint

Evidence from a Cochrane review suggests that high-dose oral therapy can be as effective as intramuscular treatment for many individuals

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25 Volkov et al., who found that benefits were regardless of B12 status, discuss the possibility that patients in their study were deficient despite serum levels being within normal limits, as no other biomarker tests were carried out