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: PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

hASCT2 IC50 = 1.2 mM) is recognized as a commercially available competitive inhibitor of rat ASCT2 transporter

It is a metabolic research tool, not a substitute for training

Levi et al., 2022)