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Given that cell-type-specific differences in the inducible expression of caspase-4 and -5 have been observed, it is possible that the same can be extended to expression of different variants especially during ISR (Salskov-Iversen et al., 2011

Our studies and others suggest that a more tunable system can ultimately have the most promise to truly model in vivo systems in vitro

First identified in the octopus Octopamine plays an important role in the innvertebrate nervous system where its role is analogous to that of norepinephrine (NE) in vertebrates, and it is responsible for the fight or flight effect and fat mobilizing

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Combination with vitamin E [83] or delivery in nanocomplexes with bilirubin [106] may further enhance its efficacy