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This condition exists in two main forms: non-alcoholic fatty liver disease (NAFLD) , affecting individuals who drink little or no alcohol, and alcohol-related liver disease (ARLD) , caused by excessive alcohol consumption

Unlike vitamin B12 deficiency, which produces well-recognised neurological and haematological manifestations, excess B12 does not typically generate a distinct clinical syndrome

However, due to concerns regarding the safety profile of broad spectrum JAKinibs [92], more specific JAKinibs are currently in development, including molecules specifically targeting JAK1 and TYK2

Fernandes-Junior et al., 2018

Retatrutide also shows meaningful improvements in metabolic markers beyond weight

doi: 10.1038/mp.2016.50 173 JesulolaEMicalosPBaguleyIJ