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Juillard, V

Cellular redox reactions play important roles not only in redox regulatory processes and antioxidant defense but also in the mechanisms of drug action and drug resistance in malaria parasites [3], [4]

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Moderately severe infection can also precipitate a haemolytic crisis in susceptible people

Furthermore, NAC (anti-oxidant via GSH upregulation) treatment increased GSH levels and clearly reduced lipid peroxidation, further supporting the notion that not only GPx4 levels but also GSH levels are a critical determinant for regulating lipid peroxidation and subsequent ferroptosis (Supplementary Fig