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An in vitro model of the bloodbrain barrier for screening nanomedicine carriers Several cell-based in vitro bloodbrain barrier models have been developed in the past to predict the permeability of nano pharmaceutical formulations to the BBB[206, 207]

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Weve shown these cells reach the brain intact. Two pathways make this possible: The Olfactory Pathway: Provides rapid, direct access to the brain through extracellular transport, with therapeutic agents reaching the olfactory bulb within minutes of administration