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Role of phospholipase C, protein kinase C, and calcium in VEGF induced venular hyperpermeability

., El, Boukhris M ., Sayadi S ., & Cherif S

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Overexpression of these growth factors is associated with glaucoma, as it disrupts ECM turnover, leading to excessive ECM accumulation in the AH outflow pathway, increasing outflow resistence and ultimately resulting in elevated IOP, which contributes to glaucoma development (83, 84)