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The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)

Numerous studies have explored the ability of antioxidants to reduce inflammation and oxidative damage by down-regulating NF-B and elevating Nrf2 (Li et al., 2016

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doi: 10.1038/s41598-017-15474-7 65 ChandelNSMcClintockDSFelicianoCEWoodTMMelendezJARodriguezAMet al

In contrast to these previous studies, our work demonstrates a direct role of a mucosal bacterial infection in eliciting specific epigenetic changes to mucosal epithelial stem cells that alter the outcome of subsequent infections