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Regardless of the use of multiple off label therapies, participants living with PBC globally had evidence of ongoing moderatesevere pruritus, underscoring the unmet need for a symptom-specific therapy targeting pruritus in PBC

Kuettner A, Pieper A, Koch J, Enzmann F, Schroeder S

The -crystallins are, themselves, normally phosphorylated in vivo and can be phosphorylated in vitro in a cyclic AMP-dependent manner

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Cuproptosis: advances in stimulus-responsive nanomaterials for cancer therapy

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