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Wang R, Gan C, Mao R, Chen Y, Yan R, Li G, Xiong T, Guo J

UCA1 silencing in cell culture stimulates miR-204 expression and downregulates IGFBP-5, inhibiting the oncogenic phenotype, and these effects are reversed by miR-204 inhibition

In mice experiments, the increase of beneficial bacteria like Muribaculaceae, Bacteroides , Alloprevotella , Parabacteroides , Lactobacill us, Phocaeicola dorei were positively related with the expression of Reg3g, Reg3b, and tight junction proteins (Occludin, Claudin-1, and ZO-1), which can effectively maintain the gut barrier homeostasis in terms of reducing ROS generation and inflammatory responses [115, 120, 137, 138]

All independently tested

We also measured the K d of MPP8 chromo with WAY(Kme3)TGK, the best CDYL2 peptide (Supplementary Figure S4C)

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