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Regulation of -opioid receptors: Desensitization, phosphorylation, internalization, and tolerance

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In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by Pyruvate Dehydrogenase and that TCA cycle flux is diminished (Gray et al., 2015, Rauckhorst et al., 2017)

illustrated that neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4), is capable of ubiquitylating as well as degrading VDAC2/3, thereby modulating ferroptotic processes in melanoma cells triggered by erastin specifically (Yang et al., 2020)