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Riccardi F, Dal Bo M, Macor P, Toffoli G

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The RAPID-OLE study, published in The Lancet in 2015, confirmed the efficacy of augmentation therapy on lung density, measured by computed tomography (CT densitometry), over a total observation and treatment period of four years

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Current clinical useparticularly within sports medicine and regenerative medicine practicesis largely based on case reports, anecdotal experience, and mechanistic rationale rather than large-scale randomized controlled trials