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doi: 10.1016/j.phrs.2015.03.010 33 ShengBWangXSuBLeeHGCasadesusGPerryGet al

Protists Unicellular eukaryotic organisms

This process involves includes many mechanisms at nanoscale (gene expression), mesoscale (changes in enzymes, ion channels, cytoskeletal proteins, receptors and secreted molecules) to macroscale (neuropathy) levels with the final common consequence of the lost retinal output to the brain (Figure 1)