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Crush injury of rat sciatic nerves and implantation of functionalized nerve protector Rats were anesthetized by intraperitoneal injection of a mixture of ketamine/xylazine (100/10 mg/kg body weight)

The wrong needle angle sends medication into muscle tissue instead of the subcutaneous fat layer where it belongs

Neuronal cell death may result from aluminium ion-induced calcium homeostasis dysregulation, which causes an aberrant increase of Ca 2+ in mitochondria and disrupts normal cellular physiological processes

YangHGaoXJLiYJSuJBZhangXNiWet al

Thus, some scholars have proposed that ferroptosis is an autophagy-dependent form of programmed cell death[73, 74] (Figure 2)

Nevertheless, at high concentrations, and in the presence of catalytic metal ions such as ferric iron (Fe 3+ ), VC can also have a pro-oxidative behavior through an indirect contribution in the Fenton reaction [6]