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Deletion of GPX4 in mice can lead to acute renal failure and ferroptosis

Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells

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Interestingly, it was reported that GH is not required for normal intrauterine growth, a finding supported by evidence that GH deficiency/insensitivity does not associate with a significant reduced size at birth[3135]