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Adolescence is the time when levels should be highest, before tapering off and then decreasing during adulthood

A cross-sectional study reported that plasma TMAO levels in T2DM patients were higher than in controls

PMID 29944175

18 , e1010212 (2022)

In addition, it also serves as a substrate for distinct metabolic pathways (such as the urea cycle) that profoundly affect immune cell biology, especially DCs, macrophages, and T cells