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MET dysregulation plays a role in regulating the expression levels of PD-L1 in tumors As noted earlier, the imbalance of MET in various tumors frequently leads to a significantly lower rate of response and effectiveness of ICIs, according to Chen et al

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"Dysregulation of ubiquitin-proteasome system in neurodegenerative diseases." Frontiers in aging neuroscience 8 (2016): 303

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That said, these molecules also have useful roles, such as fighting off infection

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