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Despite promising preliminary findings, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses

Under high oxygen conditions, NO production increases and its activity are enhanced

, Serafini M., Natella F., and Scaccini C

[DOI] [PubMed] [Google Scholar] Roa I, de Toro G, Fernndez F, et al

Serine Alleviates Oxidative Stress via Supporting Glutathione Synthesis and Methionine Cycle in Mice

This phenomenon, called aerobic glycolysis or the Warburg effect, has been exploited for visualizing tumors in the clinical setting by imaging their uptake of the radiolabeled glucose analog, [18F] fluoro-2-deoxyglucose (FDG), via Positron Emission Tomography (PET)