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The content encompasses uric acid metabolic disorders, the innate immune activation process induced by MSU crystals, as well as various subsequently triggered programmed cell death (PCD) modalities, including pyroptosis, NETosis, apoptosis, necroptosis and ferroptosis

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These kinases possess a modulatory capacity for cellular activities and might phosphorylate transcription regulators, or proteins overseeing gene modulation

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3 Oxidative posttranslational modifications of cysteines The availability of different oxidation states of thiol-sulfur allows the formation of a variety of oxidative posttranslational modifications (PTMs) on cysteines, including S-nitrosylation (or S-nitrosation, SNO), sulfhydration (SSH), disulfide bond formation (RS-SR), sulfenylation (SOH), sulfinic acid (SO 2 H), and sulfonic acid (SO 3 H) (10) ( Figure 1A )