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It was noteworthy that in fructose-induced diabetic rat model, treatment with GA increased expressions of Glut4, PPAR- and pAkt proteins, but not phosphorylated AMP-activated protein kinase (pAMPK) in the epithelial white adipose tissue, suggesting that GA attenuated insulin resistance through the Akt signalling pathway (Variya et al., 2020)

This review critically examines the therapeutic potential of two phytochemicals or natural bioactives, apigenin and ellagic acid, in the integrative management of PCOS and its associated metabolic disturbances and comorbidities