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Rhonda Patrick: I've seen some not-so-great preliminary evidence suggesting maybe time of day is important

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After washing three times with PBS, cells were fixed with 1 mL 4% paraformaldehyde for 15 min, permeabilized with 1 mL 0.1% Triton X-100 for 10 min at room temperature, and blocked with 1 mL 5% BSA for 30 min

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Youll hear influencers and even health professionals say just take methylfolate and your methylation will be fixed. Thats not how biochemistry works