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In this phase II study, 100 patients affected by chronic LBP ( 6 months) associated with 1-level moderate IDD (modified Pfirrmann score 3-6) were randomized to receive 6 10 6 MPCs with 1% HA, 18 10 6 MPCs with 1% HA, 1% HA only or sham

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The synergy might arise from the combined action of GHK-Cu in stimulating glycosaminoglycan production, promoting collagen synthesis, and HA's role in reducing collagen degradation by scavenging reactive oxygen species and inhibiting matrix metalloproteinases

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