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However, the lack of extensive human clinical trials means long-term safety data in humans remains limited

How much vitamin B12 should be taken at different stages of life

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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting

This includes vegans and vegetarians, older adults, individuals with atrophic gastritis, pernicious anemia, gastrointestinal disorders, those who have had gastrointestinal surgery and people who take certain medications including, but not limited to, estrogen (HRT), and birth control pills