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References: [1] Mendoza Mar Y, Fernndez Mayola M, Aguilera Barreto A, Garca Ojalvo A, Bermdez Alvarez Y, Mir Bentez AJ, Berlanga Acosta J

doi: 10.1371/journal.pone.0055820

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It has been recognized that exercise training triggers an increase in NO production, Ca 2+ -calmodulin kinase interaction, and adenosine monophosphate-activated protein kinase (AMPK) activation, which leads to PGC1 upregulation and activation in both skeletal and cardiac muscle cells